Plasma Technology for Health

Technology | Studies

Proven to be effective -
in every sense

Studies on the subject

Clinical applications and data

Emmert, Steffen; Brehmer, Franziska; Hänßle, Holger; Helmke, Andreas; Mertens, Nina; Ahmed, Raees et al. (2013): Atmospheric pressure plasma in dermatology: Ulcus treatment and much more. In: Clinical Plasma Medicine 1 (1), S. 24–29. DOI: 10.1016/j.cpme.2012.11.002.

" In plasma treatment antiinflammatory, antipruritic, antimicrobial, tissue stimulation, stimulation of microcirculation, and other therapeutic effects are achieved in a single treatment due to the combined action of ultraviolet radiation, reactive oxygen species (e.g. ozone), reactive nitrogen species, and electric fields. In line with other reports, we have already demonstrated the use of direct plasma treatment in skin disinfection, in atopic eczema (superinfected dermatitis), in modulating the epidermal barrier, as well as in chronic wound treatment. We as well as others did not notice any side effects of plasma treatment so far. In summary, cold atmospheric pressure plasma constitutes a new and innovative treatment option especially for superinfected skin diseases. These promising relatively new clinical applications warrant further carefully conducted translational research to delineate the modes of actions of plasma as well as potential long term side effects. This should lead to norms for the technical devices to allow a standardized treatment of given diseases in the mid-term."

Brehmer, Franziska; Haenssle, H. A.; Daeschlein, Georg; Ahmed, R.; Pfeiffer, S.; Görlitz, A. et al. (2015): Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(®) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). In: Journal of the European Academy of Dermatology and Venereology : JEADV 29 (1), S. 148–155. DOI: 10.1111/jdv.12490.

"Cold atmospheric plasma displays favourable antibacterial effects. We demonstrated that plasma treatment with the PlasmaDerm® VU-2010 device is safe and effective in patients with chronic venous leg ulcers. Thus, larger controlled trials and the development of devices with larger application surfaces are warranted."

Geimer, Till; Blatner, Carolin; Ruzicka, Thomas, Sattler, Elke (2016): Cold atmospheric plasma for the treatment of wound healing disorders: response patterns and therapy courses. Ludwig Maximillians University Munich, Clinic and Polyclinic for Dermatology and Allergology, 2016.

"These three courses make it clear that therapy with CAP - presumably due to different therapy regimes - can have various effects on tissue reconstruction. In the future, it will be necessary to clarify by means of randomized studies to what extent CAP is used for indications in which rapid re-epithelialization is to be promoted (e.g. split skin removal sites, status after laser resurfacing), for surgical wounds with slow secondary healing (e.g. secondary healing surgery - wounds in acne inversa) and of course in complex wounds, can show a therapeutic advantage. "

Hartwig, Stefan; Doll, Christian; Voss, Jan Oliver; Hertel, Moritz; Preissner, Saskia; Raguse, Jan Dirk (2017a): Treatment of Wound Healing Disorders of Radial Forearm Free Flap Donor Sites Using Cold Atmospheric Plasma: A Proof of Concept. In: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 75 (2), S. 429–435. DOI: 10.1016/j.joms.2016.08.011.

"Cold atmospheric plasma could offer a reliable conservative treatment option for complicated wound healing disturbances. This was exemplarily shown in the case of radial forearm free flap donor site morbidity with exposed flexor tendons in the present study."

Hartwig, Stefan; Preissner, Saskia; Voss, Jan Oliver; Hertel, Moritz; Doll, Christian; Waluga, Richard; Raguse, Jan Dirk (2017b): The feasibility of cold atmospheric plasma in the treatment of complicated wounds in cranio-maxillo-facial surgery.

In: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 45 (10), S. 1724–1730. DOI:
10.1016/j.jcms.2017.07.008.

"The use of cold atmospheric plasma might offer a reliable, conservative treatment option in complicated wound healing disturbances in cranio-maxillo-facial surgery."

Paulßen von Beck, Felix; Mücke, Thomas (2018): Improvement of wound healing when healing full skin with PlasmaDerm®? – A pilot study. Clinic for oral and maxillofacial surgery, plastic and aesthetic operations, Malteser Krankenhaus St. Josefshospital, Krefeld-Uerdingen. Wound Congress Nuremberg, 2018.
• Activation of wound healing
• Increase in microcirculation
• Optimization of oxygen saturation
• antimicrobial, without development of resistance
• effective against multi-resistant germs
• Reduction of postoperative wound healing disorders during ingrowth of full thickness skin grafts