” In plasma treatment antiinflammatory, antipruritic, antimicrobial, tissue stimulation, stimulation of microcirculation, and other therapeutic effects are achieved in a single treatment due to the combined action of ultraviolet radiation, reactive oxygen species (e.g. ozone), reactive nitrogen species, and electric fields. In line with other reports, we have already demonstrated the use of direct plasma treatment in skin disinfection, in atopic eczema (superinfected dermatitis), in modulating the epidermal barrier, as well as in chronic wound treatment. We as well as others did not notice any side effects of plasma treatment so far. In summary, cold atmospheric pressure plasma constitutes a new and innovative treatment option especially for superinfected skin diseases. These promising relatively new clinical applications warrant further carefully conducted translational research to delineate the modes of actions of plasma as well as potential long term side effects. This should lead to norms for the technical devices to allow a standardized treatment of given diseases in the mid-term.”