Non-thermal plasma technology emerged the medical field in an age of increasing bacterial and fungal resistance and global concerns about hygiene in different health care settings. Thus, the expectations regarding this new promising tool are very high. After teething problems different non-thermal plasma technologies were developed and used in different clinical trials in patients possessing chronic and acute wounds, diverse skin and itching diseases. The results from these trials and the preceding in vitro and ex vivo experiments opened up new fields of applications, which one had not thought of before. More than 5 years of clinical experience so far demonstrated that this plasma technology could be applied in a safe and effective setting to human beings. However, the potential and knowledge is far from being completely exhausted.

Keywords: Plasma medicine, Cold atmospheric plasma, Non-thermal plasma, Plasma, Chronic wounds, Clinical trial