Plasma Technology for Health

Technology | Studies

Cold plasma -
proven to be effective

Rajasekaran, Priyadarshini; Opländer, Christian; Hoffmeister, Dennis; Bibinov, Nikita; Suschek, Christoph Viktor; Wandke, Dirk; Awakowicz, Peter (2011): Characterization of Dielectric Barrier Discharge (DBD) on Mouse and Histological Evaluation of the Plasma-Treated Tissue. In: Plasma Processes Polym. 8 (3), S. 246–255. DOI: 10.1002/ppap.201000122.

“Atmospheric-pressure dielectric barrier discharge (DBD) in air is investigated for medical applications, especially for skin treatment. When the DBD was tested on mouse skin, a homogeneous discharge accompanied by filamentary microdischarges is observed. For characterization of the homogeneous discharge, averaged plasma parameters (namely electron density and electron velocity distribution function) and gas temperature are determined by optical emission spectroscopy, microphotography and numerical simulation. Chemical kinetics in the active plasma volume and in the afterglow is simulated. Fluxes of biologically useful molecules like nitric oxide (NO) and ozone reaching the treated surface and irradiation by UV photons are determined. Skin biopsy results show that DBD treatment causes no inflammation and no changes in the skin-collagen.”

Paulßen von Beck, Felix; Mücke, Thomas (2018): Improvement of wound healing when healing full skin with PlasmaDerm®? – A pilot study. Clinic for oral and maxillofacial surgery, plastic and aesthetic operations, Malteser Krankenhaus St. Josefshospital, Krefeld-Uerdingen. Wound Congress Nuremberg, 2018.
• Activation of wound healing
• Increase in microcirculation
• Optimization of oxygen saturation
• antimicrobial, without development of resistance
• effective against multi-resistant germs
• Reduction of postoperative wound healing disorders during ingrowth of full thickness skin grafts
Marschewski, Marcel; Hirschberg, Joanna; Omairi, Tarek; Höfft, Oliver; Vioel, Wolfgang; Emmert, Steffen; Maus-Friedrichs, Wolfgang (2012): Electron spectroscopic analysis of the human lipid skin barrier: cold atmospheric plasma-induced changes in lipid composition. In: Experimental dermatology 21 (12), S. 921–925. DOI: 10.1111/exd.12043.

" The lipids of the stratum corneum comprise the most important components of the skin barrier. In patients with ichthyoses or atopic dermatitis, the composition of the skin barrier lipids is disturbed resulting in dry, scaly, itching erythematous skin. Using the latest X-Ray Photoelectron Spectroscopy (XPS) technology, we investigated the physiological skin lipid composition of human skin and the effects of cold atmospheric plasma treatment on the lipid composition. Skin lipids were stripped off forearms of six healthy volunteers using the cyanoacrylate glue technique, plasma treated or not and then subjected to detailed XPS analysis. We found that the human lipid skin barrier consisted of 84.4% carbon (+1.3 SEM%), 10.8% oxygen (+1.0 SEM%) and 4.8% nitrogen (+0.3 SEM%). The composition of physiological skin lipids was not different in males and females. Plasma treatment resulted in significant changes in skin barrier lipid stoichiometry. The total carbon amount was reduced to 76.7%, and the oxygen amount increased to 16.5%. There was also a slight increase in nitrogen to 6.8%. These changes could be attributed to reduced C-C bonds and increased C-O, C=O, C-N and N-C-O bonds. The moderate increase in nitrogen was caused by an increase in C-N and N-C-O bonds. Our results show for the first time that plasma treatment leads to considerable changes in the human skin lipid barrier. Our proof of principle investigations established the technical means to analyse, if plasma-induced skin lipid barrier changes may be beneficial in the treatment of ichthyotic or eczematous skin."

Kuchenbecker, M.; Bibinov, Nikita; Kaemlimg, A.; Wandke, Dirk; Awakowicz, Peter; Vioel, Wolfgang (2009): Characterization of DBD plasma source for biomedical applications. In: J. Phys. D: Appl. Phys. 42 (4), S. 45212. DOI: 10.1088/0022- 3727/42/4/045212.

" The dielectric barrier discharge (DBD) plasma source for biomedical application is characterized using optical emission spectroscopy, plasma-chemical simulation and voltage–current measurements. This plasma source possesses only one electrode covered by ceramic. Human body or some other object with enough high electric capacitance or connected to ground can serve as the opposite electrode. DBD consists of a number of microdischarge channels distributed in the gas gap between the electrodes and on the surface of the dielectric. To characterize the plasma conditions in the DBD source, an aluminium plate is used as an opposite electrode. Electric parameters, the diameter of microdischarge channel and plasma parameters (electron distribution function and electron density) are determined. The gas temperature is measured in the microdischarge channel and calculated in afterglow phase. The heating of the opposite electrode is studied using probe measurement. The gas and plasma parameters in the microdischarge channel are studied at varied distances between electrodes. According to an energy balance study, the input microdischarge electric energy dissipates mainly in heating of electrodes (about 90%) and partially (about 10%) in the production of chemical active species (atoms and metastable molecules)."

Kisch, Tobias; Schleusser, Sophie; Helmke, Andreas; Mauss, Karl Ludwig; Wenzel, Eike Tilman; Hasemann, Benedikt et al. (2016b): The repetitive use of non-thermal dielectric barrier discharge plasma boosts cutaneous microcirculatory effects. In: Microvascular research 106, S. 8–13. DOI: 10.1016/j.mvr.2016.02.008.

"These data indicate that the repetitive use of non-thermal atmospheric plasma boosts and prolongs cutaneous microcirculation and might therefore be a potential tool to promote wound healing."

Kisch, Tobias; Helmke, Andreas; Schleusser, Sophie; Song, Jungin; Liodaki, Eirini; Stang, Felix Hagen et al. (2016a): Improvement of cutaneous microcirculation by cold atmospheric plasma (CAP): Results of a controlled, prospective cohort study. In: Microvascular research 104, S. 55–62. DOI: 10.1016/j.mvr.2015.12.002.

" CAP increases cutaneous tissue oxygen saturation and capillary blood flow at the radial forearm of healthy volunteers. These results support recently published data on wound healing after CAP treatment. However, further studies are needed to determine if this treatment can improve the reduced microcirculation in diabetic foot ulcers. Moreover, repetitive application protocols have to be compared with a single session treatment approach."