Plasma Technology for Health

Technologie | Studien

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Studien zum Thema

Verbesserte Wirkstoffaufnahme

Gelker, Monika; Müller-Goymann, Christel C.; Viöl, Wolfgang (2020): Plasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD. In: Skin pharmacology and physiology, S. 1–8. DOI: 10.1159/000505195.

"The direct treatment of excised human full-thickness skin with CAP, specifically a DBD, can lead to pore formation and enhances transdermal transport of sodium fluorescein."

Gelker, Monika; Müller-Goymann, Christel C.; Vioel, Wolfgang (2018): Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge. In: Clinical Plasma Medicine 9, S. 34–40. DOI: 10.1016/j.cpme.2018.02.001.

"A CAP treatment in isolated human SC was shown to dramatically reduce electrical resistance and yield a regular pattern of locally permeabilized regions. These regions were greater in number than the natural number of skin appendages and admitted the passage of small hydrophilic substances with Stokes’ radii up to 1.4 nm through human SC subsequent to 2×90 s CAP treatment. Proof-of-principle experiments with full-thickness skin (FTS) confirm these results."

Gelker, Monika; Mrotzek, Julia; Ichter, Astrid; Müller-Goymann, Christel C.; Vioel, Wolfgang (2019): Influence of pulse characteristics and power density on stratum corneum permeabilization by dielectric barrier discharge. In: Biochimica et biophysica acta. General subjects. DOI: 10.1016/j.bbagen.2019.05.014.

"Our results provide mechanistic insight into the potential of an emerging interdisciplinary technology - plasma medicine - as a prospective tool or treatment option. While it might become a safe and pain-free method to enhance skin permeation of drug substances, this is also a mechanism to keep in mind when tailoring plasma sources for other uses."

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