“A CAP treatment in isolated human SC was shown to dramatically reduce electrical resistance and yield a regular pattern of locally permeabilized regions. These regions were greater in number than the natural number of skin appendages and admitted the passage of small hydrophilic substances with Stokes’ radii up to 1.4 nm through human SC subsequent to 2×90 s CAP treatment. Proof-of-principle experiments with full-thickness skin (FTS) confirm these results.”